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KMID : 1007520140230062083
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Food Science and Biotechnology
2014 Volume.23 No. 6 p.2083 ~ p.2088
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Influence of Nanopowdered Peanut Sprouts in Collagen-induced Arthritic Mice
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Chang Yoon-Hyuk
Kim Dong-Hwi
Kwak Hae-Soo
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Abstract
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Effects of powdered and nanopowdered peanut sprouts on prevention and treatment of rheumatoid arthritis in DBA/IJ mice immunized with type II collagen were investigated. After induction of arthritis, mice were divided into groups of (1) no immunization (normal), (2) collageninduced arthritis (CIA), (3) collagen-induced arthritis treated with methotrexate (0.3 mg/kg of body weight) (MTX), (4) collagen-induced arthritis treated with powdered peanut sprouts (0.2mg/day) (PPS), and 5) collagen-induced arthritis treated with nanopowdered peanut sprouts (0.2 mg/ day) (NPPS). Feeding methotrexate, powdered, or nanopowdered peanut sprouts to arthritic mice significantly (p<0.05) decreased TNF-α, IL-1β, and IL-6 levels, compared to controls. Serum IgG1 levels for MTX, PPS, and NPPS group mice were 4,980.48, 6,178.44, and 5,776.21 pg/mL, respectively. All values were significantly (p<0.05) lower than for CIA group mice (8,290 pg/mL). Histological scores and spleen indices of NPPS group mice were significantly (p<0.05) lower than for PPS group mice
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KEYWORD
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nanotechnology, peanut sprout, rheumatoid arthritis
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